Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560266 | 0.88 | KDM1A (0.44) | KDM1ABCHENOTUMSMN1; SMN2HDAC1 | |
| SCHEMBL29380399 | 0.84 | BCHE (0.46) | KDM1ABCHELMNASMN1; SMN2HDAC1 | |
| SCHEMBL5560408 | 0.84 | BCHE (0.46) | KDM1ABCHELMNASMN1; SMN2HDAC1 | |
| Indole SCHEMBL27827279 | 0.73 | TRPA1 (0.38) | KDM1ABCHELMNASMN1; SMN2HDAC1 | |
| Quinoline SCHEMBL28294326 | 0.72 | PDE10A (0.38) | KDM1ABCHEMEN1KMT2AGPR119 | |
| SCHEMBL7004085 | 0.72 | KDM1A (0.50) | KDM1ABCHENOTUMHDAC1HDAC6 | |
| SCHEMBL8016162 | 0.72 | NOTUM (0.63) | KDM1ABCHENOTUMSMN1; SMN2HDAC1 | |
| SCHEMBL27739868 | 0.71 | BCHE (0.48) | KDM1ABCHEHDAC1HDAC6P2RX4 | |
| Oxindole SCHEMBL28307962 | 0.71 | AHR (0.44) | KDM1ABCHESMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL3707225 | 0.71 | KDM1A (0.52) | KDM1ABCHENOTUMHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408970-A1 | INDOLINES AND TETRAHYDRO-QUINOLINES AS PRODRUGS FOR TUMOUR TREATMENT | THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002067937-A1 | INDOLINE AND TETRAHYDRO-QUINOLINES AS PRODRUGS FOR TUMOUR TREATMENT | SCHOOL OF PHARMACY, UNIVERSITY OF LONDON (GB) | 2002-09-06 | — | — | WO | disclosed |