Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | RARB | P10826 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7109605 | 0.90 | RARB (0.50) | MAPTRXFP1RARBS1PR1HDAC1 | |
| SCHEMBL7112337 | 0.83 | FFAR1 (0.61) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL101148 | 0.82 | MAPT (0.54) | MAPTRXFP1CYP1A2S1PR1HDAC3 | |
| SCHEMBL31403440 | 0.81 | RARB (0.59) | RARBESR2 | |
| SCHEMBL9797528 | 0.80 | RARB (0.62) | RARBESR2 | |
| SCHEMBL5822623 | 0.80 | DGAT1 (0.56) | MAPTFFAR1ESR2 | |
| SCHEMBL9807329 | 0.78 | ESR1 (0.52) | MAPTRXFP1CYP1A2HDAC3MAPK1 | |
| SCHEMBL21415408 | 0.78 | ESR2 (0.47) | RARBESR2MMP2MMP3 | |
| SCHEMBL23512340 | 0.78 | FFAR1 (0.49) | RARBS1PR1FFAR1S1PR3S1PR5 | |
| SCHEMBL98234 | 0.78 | CYP1A2 (0.56) | MAPTRXFP1CYP1A2S1PR1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047665-B1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-10-22 | — | — | EP | disclosed |
| US-6350907-B1 | PEPTIDE ENZYME INHIBITORS | PFIZER INC | 2002-02-26 | — | — | US | disclosed |
| EP-1047665-A1 | MATRIX METALLOPROTEASE INHIBITORS | Pfizer Limited (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999035124-A1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |