Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 13/20 | 0.61 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.61 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24307632 | 0.90 | FFAR1 (0.73) | FFAR1FFAR4HTR7PLA2G10PLA2G2A | |
| SCHEMBL7112573 | 0.88 | HTR7 (0.57) | FFAR1FFAR4HTR7PLA2G10PLA2G2A | |
| SCHEMBL7763090 | 0.84 | MAPT (0.68) | FFAR1FFAR4MAPTRXFP1PLA2G10 | |
| SCHEMBL7112336 | 0.83 | MAPT (0.54) | FFAR1FFAR4MAPTRXFP1PLA2G10 | |
| SCHEMBL30541434 | 0.79 | HTR7 (0.60) | FFAR1FFAR4HTR7PLA2G10PLA2G2A | |
| SCHEMBL9194505 | 0.79 | HDAC1 (0.69) | FFAR1FFAR4MAPTRXFP1PLA2G10 | |
| SCHEMBL10279799 | 0.78 | HTR7 (0.82) | FFAR1FFAR4HTR7 | |
| SCHEMBL21475912 | 0.78 | HTR7 (0.58) | FFAR1FFAR4HTR7 | |
| SCHEMBL7108995 | 0.78 | FFAR1 (0.53) | FFAR1FFAR4MAPTHDAC3HDAC4 | |
| SCHEMBL3249491 | 0.77 | MAPT (0.62) | FFAR1FFAR4MAPTRXFP1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047665-B1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-10-22 | — | — | EP | disclosed |
| US-6350907-B1 | PEPTIDE ENZYME INHIBITORS | PFIZER INC | 2002-02-26 | — | — | US | disclosed |
| EP-1047665-A1 | MATRIX METALLOPROTEASE INHIBITORS | Pfizer Limited (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999035124-A1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |