Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 13/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7112337 | 0.88 | FFAR1 (0.61) | HTR7FFAR1FFAR4PLA2G10PLA2G2A | |
| SCHEMBL7109610 | 0.85 | RARB (0.48) | FFAR1FFAR4 | |
| SCHEMBL7109605 | 0.83 | RARB (0.50) | FFAR1 | |
| SCHEMBL24307632 | 0.80 | FFAR1 (0.73) | HTR7FFAR1FFAR4PLA2G10PLA2G2A | |
| SCHEMBL30541434 | 0.78 | HTR7 (0.60) | HTR7FFAR1FFAR4PLA2G10PLA2G2A | |
| SCHEMBL10279799 | 0.77 | HTR7 (0.82) | HTR7FFAR1FFAR4 | |
| SCHEMBL19612745 | 0.77 | NAAA (0.55) | CNR1 | |
| SCHEMBL9662576 | 0.77 | NAAA (0.55) | CNR1 | |
| SCHEMBL21475912 | 0.77 | HTR7 (0.58) | HTR7FFAR1FFAR4NR1H4 | |
| SCHEMBL7109612 | 0.76 | FFAR1 (0.50) | HTR7FFAR1FFAR4MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047665-B1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-10-22 | — | — | EP | disclosed |
| US-6350907-B1 | PEPTIDE ENZYME INHIBITORS | PFIZER INC | 2002-02-26 | — | — | US | disclosed |
| EP-1047665-A1 | MATRIX METALLOPROTEASE INHIBITORS | Pfizer Limited (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999035124-A1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |