Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | PTPRC | P08575 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14154089 | 0.89 | ALDH1A1 (0.62) | PTGS2ALDH1A1TDP1TSHRPOLB | |
| SCHEMBL629839 | 0.86 | PTGS2 (0.59) | PTGS2ALDH1A1TDP1TSHRPOLB | |
| SCHEMBL30683694 | 0.85 | ALDH1A1 (0.72) | ALDH1A1TDP1TSHRCYP3A4KMT2A | |
| SCHEMBL14565383 | 0.84 | TSHR (0.60) | ALDH1A1TDP1TSHRCYP3A4KMT2A | |
| SCHEMBL6391559 | 0.83 | PTGS2 (0.69) | PTGS2ALDH1A1TDP1TSHRPOLB | |
| SCHEMBL28207049 | 0.83 | PTGS2 (0.73) | PTGS2ALDH1A1TDP1TSHRPOLB | |
| SCHEMBL9807396 | 0.83 | ALDH1A1 (0.55) | PTGS2ALDH1A1TDP1TSHRPOLB | |
| SCHEMBL3828843 | 0.83 | ALDH1A1 (0.55) | PTGS2ALDH1A1TDP1TSHRPOLB | |
| SCHEMBL22130321 | 0.83 | ALDH1A1 (0.61) | PTGS2ALDH1A1TDP1TSHRPOLB | |
| SCHEMBL3540919 | 0.83 | ALDH1A1 (0.55) | PTGS2ALDH1A1TDP1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101245018-B | Process for producing 2-nitryl fluorenone | UNIV SHANXI | 2011-05-18 | — | — | CN | disclosed |
| US-7943645-B2 | Piperidine compounds for use as orexin receptor antagonist | SMITHKLINE BEECHAM LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| US-20090082390-A1 | PIPERIDINE COMPOUNDS FOR USE AS OREXIN RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM P.L.C. | 2009-03-26 | — | — | US | disclosed |
| US-7423052-B2 | Piperidine compounds for use as orexin receptor antagoinst | SMITHKLINE BEECHAM P.L.C. (GB) | 2008-09-09 | — | — | US | disclosed |
| CN-101245018-A | Process for producing 2-nitryl fluorenone | UNIV SHANXI (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-1152006-C | Biphenyl derivatives | - | 2004-06-02 | — | — | CN | disclosed |
| EP-1047665-B1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-10-22 | — | — | EP | disclosed |
| US-6423519-B1 | CONTACTING FUNGAL CELL WITH COMPOUND WHICH INHIBITS PRENYLTRANSFERASE ACTIVITY OF CELL, INCLUDING PERMEASE TAG WHICH FACILITATES PERMEASE-MEDIATED TRANSPORT OF COMPOUND INTO CELL, INHIBITING GROWTH THEREOF | GPC BIOTECH INC. | 2002-07-23 | — | — | US | disclosed |
| CN-1343197-A | Biphenyl derivatives as neurokinin-1 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2002-04-03 | — | — | CN | disclosed |
| US-6350907-B1 | PEPTIDE ENZYME INHIBITORS | PFIZER INC | 2002-02-26 | — | — | US | disclosed |
| EP-1144381-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| EP-1133475-A1 | SUBSTITUTED BENZO DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-09-19 | — | — | EP | disclosed |
| EP-1096925-A2 | USE OF INHIBITORS OF PRENYLTRANSFERASES FOR FOR INHIBITING FUNGAL GROWTH | MITOTIX, INC. (US) | 2001-05-09 | — | — | EP | disclosed |
| CN-1284942-A | matrix metalloproteinase inhibitors | PFIZER LTD (US) | 2001-02-21 | — | — | CN | disclosed |
| EP-1047665-A1 | MATRIX METALLOPROTEASE INHIBITORS | Pfizer Limited (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-2000003743-A9 | USE OF INHIBITORS OF PRENYLTRANSFERASES FOR INHIBITING FUNGAL GROWTH | MITOTIX INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000032577-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-08 | — | — | WO | disclosed |
| WO-2000031039-A1 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-02 | — | — | WO | disclosed |
| WO-2000003743-A2 | USE OF INHIBITORS OF PRENYLTRANSFERASES FOR INHIBITING FUNGAL GROWTH | MITOTIX, INC. (US) | 2000-01-27 | — | — | WO | disclosed |
| WO-1999035124-A1 | MATRIX METALLOPROTEASE INHIBITORS | PFIZER LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082390-A1 | PIPERIDINE COMPOUNDS FOR USE AS OREXIN RECEPTOR ANTAGONIST | HCRTR2, HCRTR1, OXTR | PTGS2 1831/4885ALDH1A1 1534/4885TDP1 4860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.