Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544387 | 0.93 | DNM1 (0.52) | DNM1LPAR1LPAR3ALDH1A1CNR1 | |
| SCHEMBL8545372 | 0.91 | DNM1 (0.55) | DNM1LPAR1LPAR3ALDH1A1CNR1 | |
| SCHEMBL711723 | 0.85 | — | — | |
| SCHEMBL12459746 | 0.85 | DNM1 (0.50) | DNM1LPAR1LPAR3CYP3A4ALDH1A1 | |
| SCHEMBL8202515 | 0.78 | DNM1 (0.45) | DNM1LPAR1LPAR3CYP3A4ALDH1A1 | |
| SCHEMBL13326798 | 0.78 | DNM1 (0.45) | DNM1LPAR1LPAR3CYP3A4ALDH1A1 | |
| SCHEMBL28858815 | 0.78 | DNM1 (0.45) | DNM1LPAR1LPAR3CYP3A4ALDH1A1 | |
| SCHEMBL28934674 | 0.77 | DNM1 (0.50) | DNM1LPAR1LPAR3ALDH1A1CNR1 | |
| SCHEMBL1904373 | 0.77 | DNM1 (0.60) | DNM1LPAR1LPAR3ALDH1A1CNR1 | |
| SCHEMBL11764032 | 0.76 | DNM1 (0.43) | DNM1LPAR1LPAR3CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239767-A2 | COMPOSITIONS AND METHODS FOR PHARMACOLOGIC TREATMENT OF STROKE AND MYOCARDIAL ISCHEMIA REPERFUSION INJURY | UNIVERSITY OF CONNECTICUT (US) | 2023-12-14 | — | — | WO | disclosed |
| US-20210205322-A1 | RICTOR-TARGETED THERAPY IN THE MANAGEMENT OF BRAIN METASTASES | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2021-07-08 | — | — | US | disclosed |
| WO-2021030174-A1 | TRUNCATED ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | UNIVERSITY OF CONNECTICUT (US) | 2021-02-18 | — | — | WO | disclosed |
| EP-3099679-B1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | UNIV CONNECTICUT (US) | 2020-05-20 | — | — | EP | disclosed |
| US-20180320177-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER FIBROSIS | UNIVERSITY OF CONNECTICUT | 2018-11-08 | — | — | US | disclosed |
| US-9650365-B2 | Itraconazole analogues and methods of use thereof | UNIVERSITY OF CONNECTICUT (US) | 2017-05-16 | — | — | US | disclosed |
| WO-2017079227-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER FIBROSIS | UNIVERSITY OF CONNECTICUT (US) | 2017-05-11 | — | — | WO | disclosed |
| EP-3099679-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | University of Connecticut (US) | 2016-12-07 | — | — | EP | disclosed |
| US-20160340346-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-11-24 | — | — | US | disclosed |
| EP-2237774-B1 | THE USE OF 6-HALOGENO-(1,2,4)-TRIAZOLO-(1,5-a)-PYRIMIDINE COMPOUNDS FOR COMBATING PESTS IN AND ON ANIMALS | MERIAL LTD (US) | 2016-06-22 | — | — | EP | disclosed |
| EP-0835248-A1 | 1-AMINO-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1998-04-15 | — | — | EP | disclosed |
| US-5733850-A | HERBICIDES, DESICCANTS OR DEFOLIANTS OF PLANTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-03-31 | — | — | US | disclosed |
| EP-0802905-A1 | SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-29 | — | — | EP | disclosed |
| WO-1997035845-A1 | SUBSTITUTED 1-METHYL-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1997-10-02 | — | — | WO | disclosed |
| WO-1997001543-A1 | 1-AMINO-3-BENZYLURACILS | BASF AKTIENGESELLSCHAFT (DE) | 1997-01-16 | — | — | WO | disclosed |
| WO-1996021645-A1 | SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1996-07-18 | — | — | WO | disclosed |
| US-4532239-A | N-phenoxypropanol-N'-pyridazinyl ethylendiamines as β-receptor blockers | CASSELLA AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |
| EP-0054946-B1 | BASIC SUBSTITUTED PYRIDAZINES, THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1984-08-15 | — | — | EP | disclosed |
| EP-0054946-A1 | Basic substituted pyridazines, their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4216314-A | CARDIOSELECTIVE B-ADRENOLYTIC AGENTS, ANTIARRHYTHMIC AGENTS AND HYPOTENSIVE AGENTS | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DE) | 1980-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340346-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | GLI1, SHH, SMO | DNM1 634/4885LPAR1 4366/4885LPAR3 2794/4885 |
| US-20210205322-A1 | RICTOR-TARGETED THERAPY IN THE MANAGEMENT OF BRAIN METASTASES | RICTOR, AKT2, MTOR | DNM1 1882/4885LPAR1 2467/4885LPAR3 2820/4885 |
| US-20180320177-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER FIBROSIS | HMGB2, HMGB3, HMGB1 | DNM1 1821/4885LPAR1 179/4885LPAR3 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.