Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116851 | 1.00 | HTT (0.44) | HTTKMT2AMEN1CYP2D6MDM2 | |
| Hydrochloric Acid SCHEMBL7164481 | 0.99 | HTT (0.46) | HTTKMT2AMEN1CYP2D6MDM2 | |
| Hydrochloric Acid SCHEMBL7164485 | 0.99 | HTT (0.46) | HTTKMT2AMEN1CYP2D6MDM2 | |
| SCHEMBL7125606 | 0.89 | KMT2A (0.51) | HTTKMT2AMEN1CYP2D6CES2 | |
| SCHEMBL7125610 | 0.89 | KMT2A (0.51) | HTTKMT2AMEN1CYP2D6CES2 | |
| SCHEMBL7115547 | 0.88 | CYP2D6 (0.49) | HTTKMT2AMEN1CYP2D6MDM2 | |
| SCHEMBL7115545 | 0.88 | CYP2D6 (0.49) | HTTKMT2AMEN1CYP2D6MDM2 | |
| SCHEMBL7121853 | 0.88 | NPC1 (0.49) | HTTKMT2AMEN1CYP2D6MDM2 | |
| Hydrochloric Acid SCHEMBL7161561 | 0.88 | KMT2A (0.50) | HTTKMT2AMEN1CYP2D6CES2 | |
| SCHEMBL7119780 | 0.88 | NPC1 (0.49) | HTTKMT2AMEN1CYP2D6MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653508-B2 | Use treating various medical conditions, including pain | GRUENENTHAL GMBH (DE) | 2003-11-25 | — | — | US | claimed |
| JP-2003505358-A | — | — | 2003-02-12 | — | — | JP | claimed |
| US-20020161262-A1 | 3-Amino-2-benzyl-1-phenylpropane derivatives | GRUENTENTHAL GMBH (DE) | 2002-10-31 | — | — | US | claimed |
| EP-1196373-A1 | 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-17 | — | — | EP | claimed |
| WO-2001005743-A1 | 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES | Grünenthal GmbH (DE) | 2001-01-25 | — | — | WO | claimed |
| US-6653508-B2 | Use treating various medical conditions, including pain | GRUENENTHAL GMBH (DE) | 2003-11-25 | — | — | US | disclosed |
| US-20020161262-A1 | 3-Amino-2-benzyl-1-phenylpropane derivatives | GRUENTENTHAL GMBH (DE) | 2002-10-31 | — | — | US | disclosed |
| EP-1196373-A1 | 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005743-A1 | 3-AMINO-2-BENZYL-1-PHENYL-PROPANE DERIVATIVES | Grünenthal GmbH (DE) | 2001-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161262-A1 | 3-Amino-2-benzyl-1-phenylpropane derivatives | PYGL, CYP11B2, GOT2 | HTT 626/4885KMT2A 3115/4885MEN1 3858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.