Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7887985 | 0.90 | KEAP1 (0.42) | KDM4EKEAP1SMN1; SMN2ALDH1A1HRH3 | |
| SCHEMBL5848078 | 0.84 | CXCR4 (0.37) | SMN1; SMN2HRH3CYP1A2GNAI3GNAO1 | |
| SCHEMBL4573391 | 0.78 | CXCR4 (0.37) | HRH3CYP1A2GNAI3GNAO1GNAI1 | |
| SCHEMBL2238689 | 0.73 | GNAO1 (0.46) | KDM4EKEAP1SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL416345 | 0.72 | SMN1; SMN2 (0.50) | KDM4EKEAP1SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL10916903 | 0.72 | KDM4E (0.55) | KDM4EKEAP1SMN1; SMN2ALDH1A1GLA | |
| Hydrochloric Acid SCHEMBL6407048 | 0.71 | GNAO1 (0.49) | KDM4EKEAP1SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL3951323 | 0.71 | SLC6A2 (0.32) | KDM4EDAOMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27141329 | 0.71 | GLA (0.48) | KDM4EKEAP1SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL6262806 | 0.71 | SLC6A2 (0.33) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309587-A1 | CINNOLINE COMPOUNDS | AstraZeneca AB (SE) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002012228-A1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |