Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7119893 | 0.95 | IGF1R (0.70) | IGF1RKMT2AALDH1A1POLBALOX5 | |
| SCHEMBL7114812 | 0.90 | IGF1R (0.73) | IGF1RKMT2AALDH1A1POLBNPC1 | |
| SCHEMBL7120457 | 0.89 | RAB9A (0.53) | IGF1RKMT2AALDH1A1POLBALOX5 | |
| SCHEMBL94596 | 0.85 | IGF1R (0.59) | IGF1RKMT2AALDH1A1POLBNPC1 | |
| SCHEMBL7122278 | 0.84 | RAB9A (0.54) | IGF1RKMT2AALDH1A1POLBALOX5 | |
| SCHEMBL4205450 | 0.83 | IGF1R (0.71) | IGF1RKMT2AALDH1A1POLBNPC1 | |
| SCHEMBL94996 | 0.82 | IGF1R (1.00) | IGF1RKMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7121375 | 0.80 | IGF1R (0.57) | IGF1RKMT2AALDH1A1POLBNPC1 | |
| SCHEMBL3131054 | 0.77 | ALDH1A1 (0.78) | IGF1RKMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7119100 | 0.76 | RAB9A (0.59) | IGF1RKMT2AALDH1A1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003035616-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-05-01 | — | — | WO | claimed |
| WO-2003035616-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-05-01 | — | — | WO | disclosed |