Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4150175 | 0.89 | KDM4E (0.42) | LMNAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7128889 | 0.86 | LMNA (0.37) | LMNAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7125756 | 0.82 | LMNA (0.46) | LMNAKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL27976815 | 0.80 | KDM4E (0.36) | LMNAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL27976888 | 0.78 | ALDH1A1 (0.41) | LMNAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL15999549 | 0.78 | KDM4E (0.39) | LMNAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL4149301 | 0.78 | KDM4E (0.57) | LMNAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7845387 | 0.77 | ALDH1A1 (0.46) | LMNAKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7122619 | 0.75 | CAPN1 (0.52) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10698481 | 0.75 | KDM4E (0.46) | LMNAKDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |