Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 8/20 | 0.61 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 5/20 | 0.55 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527132 | 0.81 | PTPN1 (0.66) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL3155581 | 0.79 | PTPN1 (0.63) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL7435640 | 0.79 | PTPN1 (0.63) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL13690232 | 0.79 | PTPN11 (0.67) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL4049597 | 0.79 | CA2 (0.67) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL11121097 | 0.79 | PTPN11 (0.72) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL25802961 | 0.79 | PTPN1 (0.63) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL7524156 | 0.79 | PTPN1 (0.63) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL6881190 | 0.79 | PTPN1 (0.63) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL25797655 | 0.79 | CA2 (0.55) | PTPN1CA2PTPN11MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |