SCHEMBL7435640

SCHEMBL7435640

[CH2]c1ccc(NS(=O)(=O)C(F)(F)F)cc1

nearest known ligand 0.63

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.63
CA2 P00918 11/20 0.61
PTPN11 Q06124 1/20 0.61
MAPK1 P28482 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
CA1 P00915 7/20 0.54
HSPD1 P10809 1/20 0.44
HSPE1 P61604 1/20 0.44
PPARA Q07869 2/20 0.40
PPARG P37231 1/20 0.40
PTGS1 P23219 1/20 0.40
PTGS2 P35354 1/20 0.40
KIF11 P52732 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7527132 0.81 PTPN1 (0.66) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL3155581 0.79 PTPN1 (0.63) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL7119686 0.79 PTPN1 (0.63) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL13690232 0.79 PTPN11 (0.67) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL11121097 0.79 PTPN11 (0.72) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL7524156 0.79 PTPN1 (0.63) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL17774980 0.79 PTPN11 (0.67) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL4049597 0.79 CA2 (0.67) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL6881190 0.79 PTPN1 (0.63) PTPN1CA2PTPN11MAPK1SMN1; SMN2
SCHEMBL15116361 0.79 PTPN1 (0.58) PTPN1CA2PTPN11MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0702013-B1 Imidazopyridines MERCK PATENT GMBH (DE) 2001-06-13 EP disclosed
US-6037349-A HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY MERCK PATENT GMBH (DE) 2000-03-14 US disclosed
US-5798364-A ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-08-25 US disclosed
US-5684015-A ANGIOTENSIN ANTAGONIST AS HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1997-11-04 US disclosed
CN-1129702-A Imidazopyridines MERCK PATENT GMBH (DE) 1996-08-28 CN disclosed
EP-0702013-A2 Imidazopyridines MERCK PATENT GmbH (DE) 1996-03-20 EP disclosed
US-5438063-A Hypotensive agents, cardiac insufficiency, increased intraocular pressure, and CNS disorders MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1995-08-01 US disclosed
EP-0657454-A1 Imidazopyridazines being angiotensin II antagonists MERCK PATENT GmbH (DE) 1995-06-14 EP disclosed
EP-0628556-A1 Imidazopyridines MERCK PATENT GmbH (DE) 1994-12-14 EP disclosed
EP-0602521-A1 Imidazopyridines MERCK PATENT GmbH (DE) 1994-06-22 EP disclosed
EP-0505893-A1 Imidazopyridines MERCK PATENT GmbH (DE) 1992-09-30 EP disclosed