Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8015438 | 0.92 | NOTUM (0.38) | NOTUMALOX5PTGS1PTGS2CYP2C19 | |
| SCHEMBL7129122 | 0.91 | HMGCR (0.38) | NOTUMALOX5PTGS1PTGS2CYP2C19 | |
| SCHEMBL8584333 | 0.87 | NOTUM (0.36) | NOTUMALOX5PTGS1PTGS2CYP2C19 | |
| SCHEMBL7119084 | 0.86 | ERN1 (0.39) | NOTUMNPSR1KCNA5KCNN4MAPT | |
| SCHEMBL7120195 | 0.85 | HMGCR (0.43) | NOTUMALOX5PTGS1PTGS2CYP2C19 | |
| SCHEMBL7130009 | 0.84 | KCNA5 (0.39) | NOTUMCYP2C19GFERNPSR1KCNA5 | |
| SCHEMBL7123787 | 0.81 | POLB (0.41) | KCNA5KCNN4ALDH1A1HTTKDM4E | |
| SCHEMBL7128246 | 0.80 | ALOX5 (0.35) | NOTUMALOX5PTGS1PTGS2KCNA5 | |
| SCHEMBL7126915 | 0.80 | PDE4D (0.42) | NOTUMCYP2C19KCNA5KCNN4MAPT | |
| SCHEMBL7119806 | 0.80 | GAA (0.44) | NOTUMCYP2C19NPSR1MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | claimed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | claimed |
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | claimed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | claimed |
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | disclosed |
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | disclosed |