Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7119806 | 0.92 | GAA (0.44) | CYP1A2RECQLGAAMAPTNOTUM | |
| SCHEMBL7119084 | 0.89 | ERN1 (0.39) | PDE4DCYP1A2BLMRECQLGAA | |
| SCHEMBL7123787 | 0.86 | POLB (0.41) | CYP1A2GAAKCNA5KCNN4POLB | |
| SCHEMBL8015438 | 0.85 | NOTUM (0.38) | PDE4DRECQLGAAMAPTKCNA5 | |
| SCHEMBL7130009 | 0.83 | KCNA5 (0.39) | RECQLGAAMAPTKCNA5KCNN4 | |
| SCHEMBL7128246 | 0.83 | ALOX5 (0.35) | BLMRECQLKCNA5ERN1KCNN4 | |
| SCHEMBL8614438 | 0.81 | ALOX5 (0.38) | KCNA5TRPV1ERN1KCNN4CYP2C9 | |
| SCHEMBL7131867 | 0.81 | ERN1 (0.34) | PDE4DRECQLGAAKCNA5ERN1 | |
| SCHEMBL8011691 | 0.81 | GAA (0.42) | CYP1A2RECQLGAAMAPTKCNA5 | |
| SCHEMBL7119797 | 0.80 | NOTUM (0.39) | MAPTKCNA5KCNN4NOTUMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | claimed |
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | claimed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | claimed |
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | disclosed |