Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7119084 | 0.90 | ERN1 (0.39) | POLBMAPK1CYP1A2L3MBTL1KDM4E | |
| SCHEMBL8015438 | 0.86 | NOTUM (0.38) | POLBL3MBTL1KDM4EKCNA5ALDH1A1 | |
| SCHEMBL7126915 | 0.86 | PDE4D (0.42) | POLBCYP1A2KCNA5KMT2AMEN1 | |
| SCHEMBL7128246 | 0.84 | ALOX5 (0.35) | POLBMAPK1L3MBTL1KCNA5KMT2A | |
| SCHEMBL8614438 | 0.82 | ALOX5 (0.38) | KCNA5KCNN4 | |
| SCHEMBL7131867 | 0.82 | ERN1 (0.34) | POLBMAPK1L3MBTL1KDM4EKCNA5 | |
| SCHEMBL7119797 | 0.81 | NOTUM (0.39) | HTTKDM4EKCNA5ALDH1A1KCNN4 | |
| SCHEMBL7119806 | 0.79 | GAA (0.44) | POLBMAPK1CYP1A2KDM4EALDH1A1 | |
| SCHEMBL7129895 | 0.79 | ERN1 (0.41) | POLBMAPK1CYP1A2L3MBTL1KDM4E | |
| SCHEMBL7130009 | 0.79 | KCNA5 (0.39) | HTTKDM4EKCNA5ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | claimed |
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | claimed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | claimed |
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | disclosed |