Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120421 | 1.00 | MAPK8 (0.42) | MAPK8ADRB2JAK1LMNAPIK3CA | |
| SCHEMBL7126732 | 0.88 | MAPK8 (0.44) | MAPK8JAK1LMNAPIK3CAMTOR | |
| SCHEMBL7126740 | 0.88 | MAPK8 (0.44) | MAPK8JAK1LMNAPIK3CAMTOR | |
| SCHEMBL7129697 | 0.83 | KDM4E (0.46) | ADRB2LMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL7129782 | 0.82 | KDM4E (0.48) | ADRB2LMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL7954575 | 0.79 | ELANE (0.46) | JAK1ALDH1A1JAK2 | |
| SCHEMBL3004100 | 0.79 | LMNA (0.50) | ADRB2LMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL22859909 | 0.77 | JAK1 (0.42) | JAK1LMNAPIK3CAMTORPRKDC | |
| SCHEMBL7512469 | 0.75 | LMNA (0.58) | ADRB2LMNAPIK3CAHPGDKDM4E | |
| SCHEMBL9148070 | 0.75 | ADRB2 (0.50) | ADRB2LMNAHPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793656-B1 | NOVEL BENZYL PYRIMIDINES | BASILEA PHARMACEUTICA AG (CH) | 2003-03-26 | — | — | EP | disclosed |
| US-5763450-A | BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0793656-A1 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016046-A2 | NOVEL BENZYL PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-30 | — | — | WO | disclosed |