Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120911 | 0.91 | ALDH1A1 (0.56) | ALDH1A1HPGDCA2PDE3BPDE3A | |
| SCHEMBL7115776 | 0.85 | KDM4E (0.41) | ALDH1A1HPGDCA2PDE3BPDE3A | |
| SCHEMBL5858114 | 0.81 | THRB (0.53) | THRATHRB | |
| SCHEMBL5861505 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HPGDHSP90AA1ESR2TDP1 | |
| SCHEMBL3982935 | 0.80 | THRA (0.54) | ALDH1A1HPGDPOLBTHRATHRB | |
| SCHEMBL10872657 | 0.76 | HSP90AA1 (0.49) | ALDH1A1HPGDCA2PDE3BPDE3A | |
| SCHEMBL7115782 | 0.76 | MEN1 (0.43) | ALDH1A1HPGDCA2PDE3BPDE3A | |
| SCHEMBL28521762 | 0.74 | ALDH1A1 (0.61) | ALDH1A1HPGDCA2PDE3BPDE3A | |
| SCHEMBL7112160 | 0.73 | BACE1 (0.52) | ALDH1A1HPGDGLAKDM4EF2 | |
| SCHEMBL5858126 | 0.72 | THRB (0.53) | ALDH1A1HPGDHSP90AA1ESR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358175-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062780-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2002-08-15 | — | — | WO | disclosed |