Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.53 |
| ▸ | MAOB | P27338 | 6/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194656 | 0.78 | SLC6A4 (0.74) | SLC6A3SLC6A4SLC6A2DRD2OPRM1 | |
| SCHEMBL14660878 | 0.75 | ALDH1A1 (0.41) | MAOBMAOAOPRM1OPRL1HTR2A | |
| SCHEMBL26947621 | 0.75 | OPRM1 (0.44) | SLC6A3SLC6A4SLC6A2SIGMAR1DRD2 | |
| SCHEMBL11173935 | 0.74 | OPRL1 (0.60) | SLC6A3SLC6A4SLC6A2SIGMAR1DRD2 | |
| SCHEMBL7456864 | 0.74 | SLC6A4 (0.49) | SLC6A3SLC6A4SLC6A2SIGMAR1DRD2 | |
| SCHEMBL1843464 | 0.74 | OPRL1 (0.60) | SLC6A3SLC6A4SLC6A2SIGMAR1DRD2 | |
| SCHEMBL11173936 | 0.74 | OPRL1 (0.60) | SLC6A3SLC6A4SLC6A2SIGMAR1DRD2 | |
| SCHEMBL10472288 | 0.72 | SLC6A3 (0.44) | SLC6A3SLC6A4SLC6A2SIGMAR1DRD2 | |
| SCHEMBL10472289 | 0.72 | SLC6A3 (0.44) | SLC6A3SLC6A4SLC6A2SIGMAR1DRD2 | |
| SCHEMBL12975991 | 0.71 | MAOB (0.47) | MAOBMAOAHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670375-B2 | Particularly, 8-aza-, 8-carbo- and 8-oxo- tropanes having 6-or 7-substituents; preferred are the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | ORGANIX, INC. | 2003-12-30 | — | — | US | disclosed |
| US-20020010207-A1 | Tropane analogs and methods for inhibition of monoamine transport | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2002-01-24 | — | — | US | disclosed |
| WO-1995011901-A9 | SUBSTITUTED 2-CARBOXYALKYL-3-(FLUOROPHENYL)-8-(3-HALOPROPEN-2-YL) NORTROPANES AND THEIR USE AS IMAGING AGENTS FOR NEURODEGENERATIVE DISORDERS | — | 1995-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010207-A1 | Tropane analogs and methods for inhibition of monoamine transport | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885SLC6A4 2/4885SLC6A2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.