Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124645 | 0.89 | NFE2L2 (0.54) | NFE2L2HSD11B1APPPTGS1FBP1 | |
| SCHEMBL7129484 | 0.89 | CYP2C19 (0.45) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3847986 | 0.81 | MAOB (0.54) | NFE2L2MAPTNPC1MEN1CYP1A2 | |
| SCHEMBL3847989 | 0.81 | MAOB (0.54) | NFE2L2MAPTNPC1MEN1CYP1A2 | |
| SCHEMBL4027579 | 0.79 | ALDH1A1 (0.46) | NFE2L2MAPTHSD11B1NPC1CYP1A2 | |
| SCHEMBL7121300 | 0.79 | HDAC2 (0.46) | NFE2L2CYP1A2PTGS1FBP1KDM4E | |
| SCHEMBL7130620 | 0.79 | HDAC2 (0.46) | NFE2L2CYP1A2PTGS1FBP1KDM4E | |
| SCHEMBL2622600 | 0.77 | APP (0.50) | MAPTMEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL9970459 | 0.77 | NFE2L2 (0.62) | NFE2L2HSD11B1APPPTGS1FBP1 | |
| SCHEMBL10137941 | 0.74 | APP (0.55) | MAPTMEN1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667346-B2 | Administration of a radioprotective alpha, beta unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces cytotoxic side effects of radiation on normal cells | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-23 | — | — | US | disclosed |
| WO-2000059494-A1 | STYRYL SULFONE ANTICANCER AGENTS | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-10-12 | — | — | WO | disclosed |