Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376107 | 0.86 | ALDH1A1 (0.50) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL7114898 | 0.85 | MAPT (0.43) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL7118031 | 0.83 | HTT (0.47) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL5858232 | 0.82 | THRB (0.53) | MAPTKMT2AMEN1POLBTHRB | |
| SCHEMBL7250246 | 0.81 | MEN1 (0.46) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL7125355 | 0.80 | MEN1 (0.45) | KMT2AMEN1ALDH1A1TUBB4ATUBB | |
| SCHEMBL12993689 | 0.77 | MAPT (0.54) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL11200639 | 0.77 | ALDH1A1 (0.52) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL7112160 | 0.77 | BACE1 (0.52) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL228433 | 0.76 | MAPT (0.55) | MAPTKMT2AMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358175-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062780-A2 | PHENOXY SUBSTITUTED BENZOCONDENSED HETEROARYL DERIVATIVES AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2002-08-15 | — | — | WO | disclosed |