Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27266235 | 0.67 | PDE10A (0.39) | ALDH1A1 | |
| SCHEMBL31584871 | 0.64 | P2RX7 (0.35) | — | |
| SCHEMBL16749053 | 0.63 | ALDH1A1 (0.44) | ALDH1A1MAPTMEN1ALOX15KMT2A | |
| SCHEMBL25833620 | 0.63 | ESR2 (0.44) | CYP3A4ALOX15ALOX12 | |
| SCHEMBL24460957 | 0.62 | MMP2 (0.38) | ALDH1A1MAPTCYP3A4MEN1KMT2A | |
| SCHEMBL21596768 | 0.61 | EPHX2 (0.40) | EPHX2 | |
| SCHEMBL14365064 | 0.60 | KDM1A (0.32) | ALDH1A1MAPT | |
| SCHEMBL866824 | 0.60 | CHRNB4 (0.41) | — | |
| SCHEMBL1979578 | 0.60 | POLB (0.37) | ALDH1A1TSHR | |
| SCHEMBL11147882 | 0.59 | ALDH1A1 (0.40) | ALDH1A1MAPTCYP2D6ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796849-B1 | NOVEL POLYCYCLIC AMINOPYRIDINE COMPOUNDS AS ACETYLCHOLINESTERASE INHIBITORS, PREPARATION PROCESS AND USE THEREOF | MEDICHEM SA (ES) | 2003-11-19 | — | — | EP | disclosed |
| US-5965569-A | TREATING MEMORY DISORDERS SUCH AS SENILE DEMENTIA OR ALZHEIMER'S DISEASE | MEDICHEM, S.A. (ES) | 1999-10-12 | — | — | US | disclosed |
| EP-0796849-A1 | NOVEL POLYCYCLIC AMINOPYRIDINE COMPOUNDS AS ACETYLCHOLINESTERASE INHIBITORS, PREPARATION PROCESS AND USE THEREOF | Camps Garcia, Pelayo (ES) | 1997-09-24 | — | — | EP | disclosed |