SCHEMBL7122408

SCHEMBL7122408

C1=Cc2cc(-c3ccccc3)ccc2CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYRO3 Q06418 1/20 0.38
NTRK2 Q16620 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
DYRK1B Q9Y463 1/20 0.38
TDP2 O95551 1/20 0.37
CA12 O43570 1/20 0.36
CA9 Q16790 1/20 0.36
PARP10 Q53GL7 1/20 0.36
PARP11 Q9NR21 1/20 0.36
ALOX5 P09917 1/20 0.35
KDM4E B2RXH2 3/20 0.35
MEN1 O00255 3/20 0.35
MAPT P10636 3/20 0.35
KMT2A Q03164 3/20 0.35
NPC1 O15118 2/20 0.35
GAA P10253 2/20 0.35
RXFP1 Q9HBX9 1/20 0.35
HSD17B3 P37058 1/20 0.34
ALDH1A1 P00352 3/20 0.33
CCR5 P51681 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25737429 0.91 TYRO3 (0.33) TYRO3NTRK2CLK4DYRK1BTDP2
SCHEMBL27353651 0.89 ASIC3 (0.37) TYRO3NTRK2CLK4DYRK1BTDP2
SCHEMBL23180124 0.88 NISCH (0.32) TYRO3NTRK2CLK4DYRK1BTDP2
SCHEMBL19444002 0.87 ALDH1A1 (0.34) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL20844728 0.87 ALDH1A1 (0.39) MEN1MAPTKMT2AGAAALDH1A1
SCHEMBL3420195 0.85 PARP10 (0.39) TYRO3NTRK2CLK4DYRK1BTDP2
SCHEMBL15704490 0.84 CYP3A4 (0.39) TDP2ALDH1A1ESR2HSD17B10ESR1
SCHEMBL21238313 0.81 TDP2 (0.32) TYRO3NTRK2CLK4DYRK1BTDP2
SCHEMBL5158791 0.81 TYRO3 (0.40) TYRO3NTRK2CLK4DYRK1BTDP2
SCHEMBL28757994 0.81 CA12 (0.41) TYRO3NTRK2CLK4DYRK1BTDP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3851443-B1 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING ORGANOMETALLIC COMPOUND, AND ELECTRONIC APPARATUS INCLUDING ORGANIC LIGHT-EMITTING DEVICE SAMSUNG ELECTRONICS CO LTD (KR) 2023-09-13 EP disclosed
EP-3988557-A1 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND Samsung Electronics Co., Ltd. (KR) 2022-04-27 EP disclosed
CN-105026372-B Histone demethylase inhibitors 赛尔基因昆蒂赛尔研究公司 2018-06-05 CN disclosed
CN-104066724-A P2X4 receptor antagonists NIPPON CHEMIPHAR CO 2014-09-24 CN disclosed
EP-1360183-A1 NOVEL PHOTOCHROMIC INDENONAPHTHOPYRAN COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2003-11-12 EP disclosed
WO-2002053553-A1 NOVEL PHOTOCHROMIC INDENONAPHTHOPYRAN COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2002-07-11 WO disclosed