Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.34 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132137 | 0.91 | PTGS2 (0.55) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL7122861 | 0.87 | PTGS2 (0.39) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL7131340 | 0.87 | PTGS2 (0.67) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL7122501 | 0.83 | PTGS2 (0.64) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL1031441 | 0.81 | PTGS2 (0.74) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL7128763 | 0.79 | PTGS2 (0.42) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| Lumiracoxib SCHEMBL6063194 | 0.75 | PTGS2 (0.87) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL6036412 | 0.74 | PTGS2 (0.59) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL7129516 | 0.74 | PTGS2 (0.53) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL1031420 | 0.71 | PTGS2 (0.83) | PTGS2PTGS1ABCB11PPARGNR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007505-B1 | CERTAIN 5-ALKYL-2-ARYLAMINOPHENYLACETIC ACIDS AND DERIVATIVES | NOVARTIS AG (CH) | 2003-04-16 | — | — | EP | claimed |