SCHEMBL712255

SCHEMBL712255

COC(=O)Nc1cc(C(=O)NS(=O)(=O)N(C)C(C)C)c(Cl)cc1F

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 19/20 0.45
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL709376 0.90 SCN9A (0.43) SCN9ACYP2C19
SCHEMBL25047105 0.86 SCN9A (0.43) SCN9ACYP2C19
SCHEMBL10242588 0.82 SCN9A (0.40) SCN9ACYP2C19
SCHEMBL25046395 0.80 SCN9A (0.42) SCN9ACYP2C19
SCHEMBL713577 0.80 SCN9A (0.46) SCN9ACYP2C19
SCHEMBL711773 0.79 HDAC6 (0.42) SCN9A
SCHEMBL31118371 0.78 SCN9A (0.45) SCN9ACYP2C19
SCHEMBL3059734 0.76 SCN9A (0.43) SCN9ACYP2C19
SCHEMBL974515 0.75 SCN9A (0.43) SCN9ACYP2C19
SCHEMBL9878589 0.71 SMN1; SMN2 (0.52) CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8252925-B2 Method for the production of 3-phenyl(thio)uracils and dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2012-08-28 US disclosed
US-8252925-B2 Method for the production of 3-phenyl(thio)uracils and dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2012-08-28 US disclosed
US-8124818-B2 Method for the production of 3-phenyl(thio) uracils and dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2012-02-28 US disclosed
US-8124818-B2 Method for the production of 3-phenyl(thio) uracils and dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2012-02-28 US disclosed
US-20110152522-A1 METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS BASF AKTIENGESSELSCHAFT (DE) 2011-06-23 US disclosed
US-20110152522-A1 METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS BASF AKTIENGESSELSCHAFT (DE) 2011-06-23 US disclosed
US-20080033174-A1 Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2008-02-07 US disclosed
US-20080033174-A1 Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils BASF AKTIENGESELLSCHAFT (DE) 2008-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080033174-A1 Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils TPMT, TYMP, TYMS SCN9A 4240/4885CYP2C19 372/4885
US-20110152522-A1 METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS TPMT, TYMP, TYMS SCN9A 4240/4885CYP2C19 372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.