Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | ACLY | P53396 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711275 | 0.91 | HDAC6 (0.41) | HDAC6HDAC8HDAC1ACLYMAPK14 | |
| SCHEMBL710134 | 0.90 | ALDH1A1 (0.47) | HDAC6HDAC8HDAC1ACLYALDH1A1 | |
| SCHEMBL711999 | 0.87 | HDAC1 (0.46) | HDAC6HDAC8HDAC1ACLYALDH1A1 | |
| SCHEMBL712003 | 0.86 | HPGD (0.47) | ALDH1A1LMNATSHRERBB2 | |
| SCHEMBL12011295 | 0.81 | HDAC6 (0.39) | HDAC6HDAC8HDAC1ACLYMAPK14 | |
| SCHEMBL712255 | 0.79 | SCN9A (0.45) | SCN9A | |
| SCHEMBL714409 | 0.79 | HDAC6 (0.43) | HDAC6HDAC8HDAC1ACLYLMNA | |
| SCHEMBL27871304 | 0.75 | ALDH1A1 (0.49) | HDAC6HDAC8HDAC1ALDH1A1LMNA | |
| SCHEMBL3080870 | 0.75 | CLPP (0.50) | ALDH1A1LMNA | |
| SCHEMBL709376 | 0.70 | SCN9A (0.43) | ALDH1A1LMNASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252925-B2 | Method for the production of 3-phenyl(thio)uracils and dithiouracils | BASF AKTIENGESELLSCHAFT (DE) | 2012-08-28 | — | — | US | disclosed |
| US-8252925-B2 | Method for the production of 3-phenyl(thio)uracils and dithiouracils | BASF AKTIENGESELLSCHAFT (DE) | 2012-08-28 | — | — | US | disclosed |
| US-8124818-B2 | Method for the production of 3-phenyl(thio) uracils and dithiouracils | BASF AKTIENGESELLSCHAFT (DE) | 2012-02-28 | — | — | US | disclosed |
| US-8124818-B2 | Method for the production of 3-phenyl(thio) uracils and dithiouracils | BASF AKTIENGESELLSCHAFT (DE) | 2012-02-28 | — | — | US | disclosed |
| US-20110152522-A1 | METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS | BASF AKTIENGESSELSCHAFT (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110152522-A1 | METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS | BASF AKTIENGESSELSCHAFT (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20080033174-A1 | Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils | BASF AKTIENGESELLSCHAFT (DE) | 2008-02-07 | — | — | US | disclosed |
| US-20080033174-A1 | Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils | BASF AKTIENGESELLSCHAFT (DE) | 2008-02-07 | — | — | US | disclosed |
| EP-1773787-A1 | METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO)URACILS AND DITHIOURACILS | BASF AKTIENGESELLSCHAFT (DE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010474-A1 | METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO)URACILS AND DITHIOURACILS | BASF AKTIENGESELLSCHAFT (DE) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033174-A1 | Method for the Production of 3-Phenyl (Thio) Uracils and Dithiouracils | TPMT, TYMP, TYMS | HDAC6 2437/4885HDAC8 4101/4885HDAC1 2627/4885 |
| US-20110152522-A1 | METHOD FOR THE PRODUCTION OF 3-PHENYL(THIO) URACILS AND DITHIOURACILS | TPMT, TYMP, TYMS | HDAC6 2437/4885HDAC8 4101/4885HDAC1 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.