Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117957 | 0.99 | GAA (0.51) | GAAALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL7120505 | 0.87 | GAA (0.50) | GAAALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL7121033 | 0.86 | KDM4E (0.42) | GAAALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL7116591 | 0.83 | GAA (0.50) | GAAALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL11151986 | 0.81 | GAA (0.53) | GAAALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL7121032 | 0.79 | GAA (0.46) | GAAALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL7127271 | 0.78 | GAA (0.43) | GAAALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL9651420 | 0.78 | CYP2C19 (0.63) | GAAALDH1A1KDM4EMAPTUSP2 | |
| Hydrochloric Acid SCHEMBL11155467 | 0.78 | GAA (0.54) | GAAALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL6466132 | 0.77 | ALDH1A1 (0.51) | GAAALDH1A1KDM4EMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1359888-A1 | COUPLERS FOR OXIDATIVE COLORATION OF HAIR | P&G-Clairol, Inc. (US) | 2003-11-12 | — | — | EP | disclosed |
| US-20020144700-A1 | Couplers for oxidative coloration of hair | CLAIROL INCORPORATED | 2002-10-10 | — | — | US | disclosed |
| WO-2002058659-A1 | COUPLERS FOR OXIDATIVE COLORATION OF HAIR | P&G-CLAIROL, INC. (US) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020144700-A1 | Couplers for oxidative coloration of hair | CBR1, CBR3, MT-CO1 | ACHE 4558/4885GAA 4787/4885ALDH1A1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.