Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.51 |
| ▸ | RELA | Q04206 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29985725 | 1.00 | ALDH1A1 (0.51) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27745558 | 0.90 | SMN1; SMN2 (0.56) | ALDH1A1HPGDSMN1; SMN2NOTUMMAPT | |
| Hydrochloric Acid SCHEMBL1859868 | 0.88 | SMN1; SMN2 (0.54) | ALDH1A1HPGDSMN1; SMN2NOTUMMAPT | |
| SCHEMBL5120536 | 0.86 | NOTUM (0.50) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL31488059 | 0.84 | NOTUM (0.57) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL28650278 | 0.78 | MAPT (0.53) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL307373 | 0.78 | TSHR (0.45) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7045087 | 0.78 | NPC1 (0.61) | ALDH1A1SMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL4984050 | 0.77 | SIGMAR1 (0.51) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL11348161 | 0.77 | SIGMAR1 (0.43) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100334076-C | Indoline derivatives and their use as 5-HT2Use of receptor ligands | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-29 | — | — | CN | disclosed |
| EP-1328515-A1 | INDOLINE DERIVATIVES AND THEIR USE AS 5-HT2 RECEPTOR LIGANDS | F. Hoffmann-La Roche AG (CH) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002044152-A1 | INDOLINE DERIVATIVES AND THEIR USE AS 5-HT2 RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-06 | — | — | WO | disclosed |