Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120536 | 0.84 | NOTUM (0.50) | SIGMAR1LMNAGAAALDH1A1KMT2A | |
| SCHEMBL4984050 | 0.83 | SIGMAR1 (0.51) | SIGMAR1LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL11644046 | 0.78 | NOTUM (0.47) | CDK4CCND1NOTUM | |
| SCHEMBL11408052 | 0.78 | BCAT2 (0.48) | ALDH1A1KMT2ANPC1SMN1; SMN2RAB9A | |
| SCHEMBL7126729 | 0.77 | ALDH1A1 (0.51) | LMNAGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL29985725 | 0.77 | ALDH1A1 (0.51) | LMNAGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL31488059 | 0.76 | NOTUM (0.57) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL5698473 | 0.76 | ALDH1A1 (0.48) | SIGMAR1LMNAGAAALDH1A1KMT2A | |
| SCHEMBL1716131 | 0.75 | SMN1; SMN2 (0.56) | SIGMAR1GAAALDH1A1KMT2AMEN1 | |
| SCHEMBL11640812 | 0.75 | SIGMAR1 (0.50) | SIGMAR1LMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586170-B | Indolinyl acyl derivative and synthetic method of isoquinoline formyl derivative | 江苏集萃分子工程研究院有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-117586170-A | Indolinyl acyl derivative and synthetic method of isoquinoline formyl derivative | 江苏集萃分子工程研究院有限公司 | 2024-02-23 | — | — | CN | disclosed |
| EP-0000151-B1 | 1-SUBSTITUTED AMINOINDOLINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANDOZ AG (CH) | 1981-05-20 | — | — | EP | disclosed |
| EP-0000151-A1 | 1-Substituted aminoindolines, process for their production and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1979-01-10 | — | — | EP | disclosed |