Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.53 |
| ▸ | GSK3A | P49840 | 9/20 | 0.53 |
| ▸ | SGK1 | O00141 | 4/20 | 0.47 |
| ▸ | AXL | P30530 | 6/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7126812 | 0.77 | GSK3A (0.64) | GSK3BGSK3ASGK1AXLCHEK1 | |
| SCHEMBL29930893 | 0.74 | GSK3B (0.58) | GSK3BGSK3AAXLCDK8TNIK | |
| SCHEMBL7128018 | 0.73 | GSK3A (0.58) | GSK3BGSK3ASGK1AXLCAMKK2 | |
| SCHEMBL5387619 | 0.72 | GSK3B (0.59) | GSK3BGSK3ASGK1AXLCDK8 | |
| SCHEMBL7168419 | 0.71 | GSK3B (0.56) | GSK3BGSK3ASGK1AXLCDK8 | |
| SCHEMBL5390676 | 0.71 | GSK3B (0.69) | GSK3BGSK3AMAP4K4CDK1CDK2 | |
| SCHEMBL16704792 | 0.70 | GSK3A (0.70) | GSK3BGSK3AMAP4K4CDK1CDK2 | |
| SCHEMBL7256635 | 0.70 | GSK3A (0.67) | GSK3BGSK3ACDK8 | |
| SCHEMBL29930698 | 0.70 | DYRK1A (0.60) | GSK3BGSK3ASGK1AXLCAMKK2 | |
| SCHEMBL12342977 | 0.69 | CYP3A4 (0.62) | GSK3BGSK3AAXLTNIKPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003045949-A1 | PYRAZOLOPYRIDINE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-05 | — | — | WO | disclosed |