Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27605086 | 0.87 | DYRK1A (0.62) | DYRK1BDYRK1AMKNK1MKNK2DYRK2 | |
| SCHEMBL4385980 | 0.86 | DYRK1A (0.60) | DYRK1BDYRK1AMKNK1MKNK2DYRK2 | |
| SCHEMBL5605301 | 0.82 | MMP12 (0.52) | DYRK1BDYRK1ACHEK1 | |
| SCHEMBL5605556 | 0.80 | HDAC6 (0.62) | MKNK1MKNK2CYP1A2CYP3A4 | |
| SCHEMBL5605206 | 0.75 | MKNK1 (0.59) | DYRK1BDYRK1AMKNK1MKNK2DYRK2 | |
| SCHEMBL6142324 | 0.75 | MMP12 (0.47) | DYRK1ACHEK1CHEK2 | |
| SCHEMBL7933423 | 0.75 | DYRK1A (0.68) | DYRK1BDYRK1AMKNK1MKNK2DYRK2 | |
| SCHEMBL6852049 | 0.75 | DYRK1A (0.54) | DYRK1BDYRK1ADYRK2CYP1A2CYP3A4 | |
| SCHEMBL6852045 | 0.75 | DYRK1A (0.54) | DYRK1BDYRK1ADYRK2CYP1A2CYP3A4 | |
| SCHEMBL30761107 | 0.74 | MKNK1 (0.59) | MKNK1MKNK2CYP1A2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | claimed |
| CN-100345847-C | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | disclosed |
| US-20030008867-A1 | Compounds | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008867-A1 | Compounds | DRD2, DRD1, GRIN2A | DYRK1B 3169/4885DYRK1A 2638/4885MKNK1 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.