Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 4/20 | 0.49 |
| ▸ | CCNC | P24863 | 3/20 | 0.49 |
| ▸ | CHUK | O15111 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 5/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.46 |
| ▸ | ALAD | P13716 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142324 | 0.85 | MMP12 (0.47) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL27624013 | 0.85 | MMP12 (0.51) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL4381926 | 0.83 | ALAD (0.66) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL5605556 | 0.83 | HDAC6 (0.62) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL7127091 | 0.82 | DYRK1B (0.58) | CHEK1DYRK1ADYRK1B | |
| SCHEMBL6143622 | 0.81 | ALAD (0.69) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL24176394 | 0.80 | ALAD (0.72) | MMP12MMP13CHUKALADMAP4K4 | |
| SCHEMBL3196052 | 0.79 | ALAD (0.56) | MMP12MMP13ALADHDAC6 | |
| SCHEMBL6141881 | 0.77 | MMP12 (0.48) | MMP12ALADGSK3BAURKBTBK1 | |
| SCHEMBL8342325 | 0.77 | ALAD (0.46) | MMP12MMP13MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545537-B1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2007-04-04 | — | — | EP | claimed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | claimed |
| CN-100345847-C | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | disclosed |