SCHEMBL7127624

SCHEMBL7127624

CN(CCN(C)C(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.45
HSD17B10 Q99714 1/20 0.44
ALDH1A1 P00352 2/20 0.42
MEN1 O00255 1/20 0.42
POLB P06746 1/20 0.42
KMT2A Q03164 1/20 0.42
DRD4 P21917 1/20 0.37
SLC6A9 P48067 1/20 0.36
KDM4E B2RXH2 1/20 0.35
MDM2 Q00987 1/20 0.35
S1PR1 P21453 1/20 0.35
CACNA2D1 P54289 1/20 0.33
CACNA1B Q00975 1/20 0.33
CACNB1 Q02641 1/20 0.33
CACNA1C Q13936 1/20 0.33
NPC1 O15118 1/20 0.33
LMNA P02545 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22954478 0.89 SIGMAR1 (0.41) SIGMAR1HSD17B10ALDH1A1MEN1POLB
SCHEMBL22954477 0.89 SIGMAR1 (0.41) SIGMAR1HSD17B10ALDH1A1MEN1POLB
SCHEMBL20187636 0.86 HSD17B10 (0.42) SIGMAR1HSD17B10ALDH1A1MEN1POLB
SCHEMBL20457594 0.83 ALDH1A1 (0.58) HSD17B10ALDH1A1MEN1POLBKMT2A
SCHEMBL31679340 0.82 HSD17B10 (0.45) SIGMAR1HSD17B10ALDH1A1MEN1POLB
SCHEMBL31679390 0.82 HSD17B10 (0.45) SIGMAR1HSD17B10ALDH1A1MEN1POLB
SCHEMBL12608912 0.81 SIGMAR1 (0.42) SIGMAR1HSD17B10ALDH1A1MEN1POLB
SCHEMBL9612256 0.80 MEN1 (0.39) SIGMAR1ALDH1A1MEN1POLBKMT2A
SCHEMBL8328859 0.79 HSD17B10 (0.40) SIGMAR1HSD17B10ALDH1A1MEN1POLB
SCHEMBL23139135 0.79 SIGMAR1 (0.40) SIGMAR1HSD17B10ALDH1A1MEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0722442-B1 POLYAZACYCLOALKANES AS DICHELANTS NYCOMED SALUTAR INC (US) 2003-01-15 EP disclosed
US-5972307-A ADMINISTERING TO HUMAN OR ANIMAL BODY AN EFFECTIVE AMOUNT OF A DIAGNOSTIC AGENT COMPRISES A METAL CHELATE OF A COMPOUND HAVING TWO MACROCYCLIC CHELANT GROUPS LINKED BY A BRIDGE CONTAINING ESTER OR AMIDE BOND NYCOMED SALUTAR, INC. (US) 1999-10-26 US disclosed
US-5650133-A CHELATING AGENTS USEFUL IN DIAGNOSTIC AND THERAPEUTIC COMPOSITIONS NYCOMED SALUTAR (US) 1997-07-22 US disclosed
WO-1995009848-A2 POLYAZACYCLOALKANES AS DICHELANTS NYCOMED SALUTAR, INC. (US) 1995-04-13 WO disclosed