Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.45 |
| ▸ | ABAT | P80404 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5663406 | 0.91 | ALOX5 (0.56) | ALOX5PTGS2KDM4EPTGS1ALDH1A1 | |
| SCHEMBL8942444 | 0.85 | ALOX5 (0.56) | ALOX5PTGS2KDM4EPTGS1ALDH1A1 | |
| SCHEMBL3987666 | 0.85 | EGFR (0.54) | ALOX5PTGS2KDM4EALDH1A1HPGD | |
| SCHEMBL929915 | 0.82 | ALDH1A1 (0.51) | ALOX5PTGS2KDM4EPTGS1ALDH1A1 | |
| SCHEMBL8155224 | 0.81 | ALDH1A1 (0.50) | ALOX5PTGS2KDM4EPTGS1ALDH1A1 | |
| SCHEMBL8165885 | 0.81 | ALOX5 (0.49) | ALOX5PTGS2KDM4EPTGS1ALDH1A1 | |
| Syringaldehyde SCHEMBL28642631 | 0.80 | ALDH1A1 (0.60) | PTGS2KDM4EPTGS1ALDH1A1TRIM24 | |
| SCHEMBL1134607 | 0.80 | KDM4E (0.49) | ALOX5PTGS2KDM4EPTGS1ALDH1A1 | |
| SCHEMBL28880304 | 0.79 | KDM4E (0.47) | ALOX5PTGS2KDM4EPTGS1ALDH1A1 | |
| SCHEMBL7196531 | 0.79 | ALDH1A1 (0.47) | ALOX5ALDH1A1TRIM24HPGDALDH5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660724-B1 | Aminophosphonates alpha substituted by phenol; lipoprotein lowering activity | ILEX PRODUCTS, INC. | 2003-12-09 | — | — | US | disclosed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | disclosed |
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | disclosed |