Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.51 |
| ▸ | ABAT | P80404 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 3/20 | 0.48 |
| ▸ | PTGES | O14684 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL929915 | 0.89 | ALDH1A1 (0.51) | ALOX5PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL5663406 | 0.88 | ALOX5 (0.56) | ALOX5PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL8155224 | 0.88 | ALDH1A1 (0.50) | ALOX5PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL1134607 | 0.86 | KDM4E (0.49) | ALOX5PTGS1PTGS2KDM4EALDH1A1 | |
| SCHEMBL7127829 | 0.85 | ALOX5 (0.59) | ALOX5PTGS1PTGS2KDM4EALDH1A1 | |
| Syringaldehyde SCHEMBL28294707 | 0.85 | ALDH1A1 (0.55) | ALOX5PTGS1PTGS2KDM4EALDH1A1 | |
| Syringaldehyde SCHEMBL150376 | 0.85 | ALDH1A1 (0.62) | PTGS1PTGS2KDM4EALDH1A1TRIM24 | |
| Syringaldehyde SCHEMBL30119623 | 0.85 | ALDH1A1 (0.62) | PTGS1PTGS2KDM4EALDH1A1TRIM24 | |
| Syringaldehyde SCHEMBL2110596 | 0.85 | ALDH1A1 (0.62) | PTGS1PTGS2KDM4EALDH1A1TRIM24 | |
| SCHEMBL28561856 | 0.84 | ALOX5 (0.55) | ALOX5PTGS1PTGS2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885306-B1 | IMIDAZO[2,1]THIAZOL-3-ONE DERIVATIVES USEFUL AS DIAGNOSTIC AGENTS FOR ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2016-06-01 | — | — | EP | disclosed |
| EP-2885306-A1 | IMIDAZO[2,1]THIAZOL-3-ONE DERIVATIVES USEFUL AS DIAGNOSTIC AGENTS FOR ALZHEIMER'S DISEASE | F. Hoffmann-La Roche AG (CH) | 2015-06-24 | — | — | EP | disclosed |
| US-20150157739-A1 | Imidazo[2,1]thiazol-3-one derivatives | HOFFMANN-LA ROCHE INC. (US) | 2015-06-11 | — | — | US | disclosed |
| WO-2014026881-A1 | IMIDAZO[2,1]THIAZOL-3-ONE DERIVATIVES USEFUL AS DIAGNOSTIC AGENTS FOR ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-20 | — | — | WO | disclosed |
| US-5480674-A | ETHYL ESTER, CITRUS OIL, 4-HYDROXY-2,5-DIMETHYL-3-FURANONE, FRUIT FLAVOR | FIRMENICH INCORPORATED (US) | 1996-01-02 | — | — | US | disclosed |
| EP-0334119-B1 | COMPOUNDS FOR INHIBITING THE BIOSYNTHESIS OF LIPOXYGENASE-DERIVED METABOLITES OF ARACHIDONIC ACID | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1993-06-16 | — | — | EP | disclosed |
| EP-0334119-A1 | Compounds for inhibiting the biosynthesis of lipoxygenase-derived metabolites of arachidonic acid | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1989-09-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150157739-A1 | Imidazo[2,1]thiazol-3-one derivatives | MAPT, SNCA, PARK7 | ALOX5 4761/4885PTGS1 3491/4885PTGS2 3832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.