Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.45 |
| ▸ | CHRND | Q07001 | 5/20 | 0.44 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.44 |
| ▸ | CHRNG | P07510 | 3/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.44 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127958 | 0.85 | PTPN1 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4PTPN1 | |
| SCHEMBL7571008 | 0.80 | PTPN1 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4PTPN1 | |
| SCHEMBL7569835 | 0.80 | PTPN1 (0.67) | PTPN1PTPRA | |
| SCHEMBL7066343 | 0.78 | PTPN1 (0.57) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL7065637 | 0.77 | PTPN1 (0.51) | PTPN1CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL7571014 | 0.77 | PTPN1 (0.52) | CHRNB2CHRNB4CHRNA3CHRNA4PTPN1 | |
| SCHEMBL7065286 | 0.77 | DPP7 (0.49) | GRIA1 | |
| SCHEMBL10545669 | 0.72 | CHRNB2 (0.67) | CHRNB2CHRNB4CHRNA3CHRNA4CHRND | |
| SCHEMBL988166 | 0.72 | CHRNB2 (0.77) | CHRNB2CHRNB4CHRNA3CHRNA4CHRND | |
| SCHEMBL5933899 | 0.71 | EGFR (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313696-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018323-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2002-03-07 | — | — | WO | disclosed |