Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.60 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CHRND | Q07001 | 6/20 | 0.52 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.52 |
| ▸ | CHRNG | P07510 | 2/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571008 | 0.87 | PTPN1 (0.58) | PTPN1GRIA1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7127951 | 0.85 | CHRNB2 (0.47) | PTPN1GRIA1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7569835 | 0.82 | PTPN1 (0.67) | PTPN1 | |
| SCHEMBL988166 | 0.80 | CHRNB2 (0.77) | GRIA1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7571014 | 0.80 | PTPN1 (0.52) | PTPN1GRIA1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7066343 | 0.80 | PTPN1 (0.57) | PTPN1GRIA1 | |
| SCHEMBL12324830 | 0.79 | CHRNB2 (0.69) | PTPN1GRIA1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6438848 | 0.79 | CHRNB2 (0.69) | PTPN1GRIA1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL16247369 | 0.79 | CHRNB2 (0.69) | PTPN1GRIA1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9519035 | 0.79 | CHRNB2 (0.69) | PTPN1GRIA1CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313696-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018323-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2002-03-07 | — | — | WO | disclosed |