Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 4/20 | 0.41 |
| ▸ | CES1 | P23141 | 4/20 | 0.41 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | PRKCG | P05129 | 2/20 | 0.37 |
| ▸ | PRKCB | P05771 | 2/20 | 0.37 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9862658 | 1.00 | CES2 (0.46) | CES2THRBGMNNTP53POLB | |
| SCHEMBL14306294 | 0.95 | CES2 (0.41) | CES2THRBGMNNTP53POLB | |
| SCHEMBL29492071 | 0.95 | CES2 (0.46) | CES2THRBGMNNTP53POLB | |
| SCHEMBL11658097 | 0.92 | CES2 (0.43) | CES2THRBGMNNTP53POLB | |
| SCHEMBL7132002 | 0.90 | CES2 (0.37) | CES2THRBGMNNTP53POLB | |
| SCHEMBL10929907 | 0.90 | CA2 (0.50) | CES2THRBGMNNTP53POLB | |
| SCHEMBL11096720 | 0.90 | CA2 (0.50) | CES2THRBGMNNTP53POLB | |
| SCHEMBL24362145 | 0.86 | THRB (0.57) | CES2THRBGMNNTP53POLB | |
| SCHEMBL199156 | 0.86 | THRB (0.57) | CES2THRBGMNNTP53POLB | |
| SCHEMBL9580049 | 0.86 | THRB (0.57) | CES2THRBGMNNTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503938-B1 | Treatment of estrogen related disease or tumor, including prostatic hyperplasia, breast cancer, endometrial carcinoma, anovulatory infertility, melanoma or osteoporosis | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-07 | — | — | US | disclosed |
| US-6147105-A | USE IN THE TREATMENT OF ESTROGEN-RELATED DISEASES | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-11-14 | — | — | US | disclosed |