Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.63 |
| ▸ | FLT1 | P17948 | 11/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.63 |
| ▸ | EGFR | P00533 | 8/20 | 0.63 |
| ▸ | FLT4 | P35916 | 6/20 | 0.63 |
| ▸ | RET | P07949 | 4/20 | 0.48 |
| ▸ | KIF5B | P33176 | 4/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604150 | 0.93 | KDR (0.64) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL2200924 | 0.85 | KDR (0.74) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL7482777 | 0.85 | KDR (0.62) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL5912648 | 0.79 | ENPP1 (0.43) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL2136908 | 0.78 | EGFR (1.00) | KDRFLT1FGFR1EGFRFLT4 | |
| Trifluoroacetic Acid SCHEMBL6902285 | 0.78 | KDR (0.65) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL1008026 | 0.77 | KDR (0.72) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL7866068 | 0.77 | KDR (0.80) | KDRFLT1FGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL6454560 | 0.76 | KDR (0.71) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL2203010 | 0.76 | FLT1 (0.73) | KDRFLT1FGFR1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244647-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001032651-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |