Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.69 |
| ▸ | CCR9 | P51686 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481856 | 0.85 | NOD2 (0.55) | CCR2PTGS2 | |
| SCHEMBL8483705 | 0.84 | CCR2 (0.51) | CCR2PTGS2 | |
| SCHEMBL15712743 | 0.84 | CCR2 (0.77) | CCR2 | |
| SCHEMBL27663338 | 0.83 | CCR2 (0.71) | CCR2CCR9ABCB11MCL1 | |
| SCHEMBL7129310 | 0.83 | CCR2 (0.48) | CCR2PTGS2 | |
| SCHEMBL6302535 | 0.81 | CCR2 (1.00) | CCR2ABCB11 | |
| SCHEMBL6303781 | 0.81 | CCR2 (0.79) | CCR2ABCB11 | |
| SCHEMBL4204898 | 0.81 | CCR2 (0.71) | CCR2CCR9ABCB11 | |
| SCHEMBL6306900 | 0.81 | CCR2 (0.71) | CCR2CCR9ABCB11PTGS2 | |
| SCHEMBL15642750 | 0.80 | CCR2 (0.76) | CCR2CCR9ABCB11MCL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |
| US-5859044-A | TREATING DIABETES, HYPERGLYCEMIA, OBESITY; INCREASING CONTENT OF LEAN MEAT IN ANIMALS | PFIZER INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0822185-A1 | B-3-adrenergic agonists as antidiabetic and antiobesity agents | PFIZER INC. (US) | 1998-02-04 | — | — | EP | disclosed |