Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7129308 | 0.83 | CCR2 (0.69) | CCR2PTGS2 | |
| SCHEMBL7071931 | 0.83 | CCR2 (0.72) | CCR2SMN1; SMN2NPSR1HTT | |
| SCHEMBL7074174 | 0.80 | CCR2 (0.61) | CCR2MEN1KMT2ACFTRALDH1A1 | |
| SCHEMBL8481856 | 0.78 | NOD2 (0.55) | CCR2MEN1KMT2APIK3R1PIK3CA | |
| SCHEMBL7076382 | 0.78 | CCR2 (0.51) | CCR2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8483705 | 0.77 | CCR2 (0.51) | CCR2CFTRSRCPTGS2 | |
| SCHEMBL8131716 | 0.75 | MAPT (0.50) | CCR2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5681505 | 0.75 | CCR2 (0.53) | CCR2ALDH1A1KDM4E | |
| SCHEMBL7077284 | 0.75 | CCR2 (0.48) | CCR2MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL6177863 | 0.75 | CCR2 (0.43) | CCR2MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |