Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 12/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921990 | 0.97 | PNMT (0.61) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL6398473 | 0.96 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL6394229 | 0.96 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL6394237 | 0.96 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1202143 | 0.82 | PNMT (0.61) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1491480 | 0.82 | PNMT (0.63) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1491483 | 0.82 | PNMT (0.63) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL11167697 | 0.82 | PNMT (0.63) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL6391507 | 0.82 | PNMT (0.63) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL2081344 | 0.81 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074256-A1 | TETRAHYDROISOQUINOLINYL SULFAMIC ACIDS | THE PROCTER & GAMBLE COMPANY (US) | 2004-09-02 | — | — | WO | disclosed |