Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366373 | 0.90 | KDR (0.36) | KDRPDPK1RETNPC1CCNE2 | |
| SCHEMBL7132017 | 0.86 | NPC1 (0.44) | KDRPDPK1RETNPC1CCNE2 | |
| SCHEMBL7131343 | 0.86 | NPC1 (0.56) | KDRPDPK1RETNPC1CCNE2 | |
| SCHEMBL5377075 | 0.84 | NPC1 (0.42) | KDRPDPK1RETNPC1CCNE2 | |
| SCHEMBL7136994 | 0.81 | MAOA (0.44) | KDRPDPK1RETPDGFRBMEN1 | |
| SCHEMBL7131380 | 0.81 | IKBKB (0.35) | KDRPDPK1RETNPC1PDGFRB | |
| SCHEMBL5377025 | 0.80 | RET (0.54) | KDRRETNPC1PDGFRBEGFR | |
| SCHEMBL7136802 | 0.80 | LRRK2 (0.43) | KDRRETCCNE2CCNE1CDK2 | |
| SCHEMBL7139913 | 0.79 | RAF1 (0.42) | RETPDGFRBEGFRMEN1KMT2A | |
| SCHEMBL7138200 | 0.79 | MEN1 (0.47) | NPC1CCNE2CCNE1CDK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |