Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138252 | 0.87 | ERBB2 (0.45) | LRRK2RETPLK4PSEN1PSEN2 | |
| SCHEMBL7139913 | 0.85 | RAF1 (0.42) | LRRK2RETPLK4PSEN1PSEN2 | |
| SCHEMBL7136994 | 0.84 | MAOA (0.44) | RETPLK4KDRRAF1 | |
| SCHEMBL7134022 | 0.83 | LRRK2 (0.48) | LRRK2RETPSEN1PSEN2APH1B | |
| SCHEMBL7134014 | 0.83 | RET (0.48) | LRRK2RETPLK4RAF1 | |
| SCHEMBL7133808 | 0.82 | DYRK1A (0.37) | LRRK2RETKDRRAF1DYRK1A | |
| SCHEMBL7134020 | 0.82 | LRRK2 (0.49) | LRRK2RETPSEN1PSEN2APH1B | |
| SCHEMBL5363090 | 0.82 | LRRK2 (0.60) | LRRK2PLK4PSEN1PSEN2APH1B | |
| SCHEMBL7133405 | 0.82 | LRRK2 (0.46) | LRRK2RETPLK4PSEN1PSEN2 | |
| SCHEMBL5366852 | 0.81 | LRRK2 (0.50) | LRRK2RETPLK4PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |