Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139913 | 0.89 | RAF1 (0.42) | PIM1PIM2RETMEN1KMT2A | |
| SCHEMBL7134020 | 0.86 | LRRK2 (0.49) | MAOAMAOBPIM1PIM2RET | |
| SCHEMBL5377025 | 0.84 | RET (0.54) | PIM1RETMEN1KMT2APDGFRB | |
| SCHEMBL7136802 | 0.84 | LRRK2 (0.43) | RETPLK4KDRRAF1 | |
| SCHEMBL7134866 | 0.83 | LRRK2 (0.50) | PIM1PIM2RETMEN1KMT2A | |
| SCHEMBL7134444 | 0.83 | PIM1 (0.43) | MAOAMAOBPIM1PIM2RET | |
| SCHEMBL7130447 | 0.81 | KDR (0.40) | RETMEN1KMT2AIKBKBFLT3 | |
| SCHEMBL7138200 | 0.81 | MEN1 (0.47) | MEN1KMT2AFLT3PDGFRB | |
| SCHEMBL7130522 | 0.80 | ADAMTS5 (0.51) | MAOAMAOBRETMEN1KMT2A | |
| SCHEMBL14673674 | 0.80 | MAOA (0.48) | MAOAMAOBPIM1PIM2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |