Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | FCER2 | P06734 | 1/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | YES1 | P07947 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368747 | 0.91 | SRC (0.51) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL7131357 | 0.90 | SYK (0.57) | ADAMTS5SYKNTRK1FCER2NTRK3 | |
| SCHEMBL7133282 | 0.90 | NTRK1 (0.51) | ADAMTS5SYKNTRK1FCER2NTRK3 | |
| SCHEMBL7140266 | 0.87 | MOGAT2 (0.50) | ADAMTS5SYK | |
| SCHEMBL7132857 | 0.87 | SYK (0.47) | ADAMTS5SYKNTRK1FCER2NTRK3 | |
| SCHEMBL7137038 | 0.86 | SYK (0.49) | ADAMTS5SYKNTRK1FCER2NTRK3 | |
| SCHEMBL7135152 | 0.85 | SRC (0.55) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL7136635 | 0.85 | NTRK1 (0.55) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL7132123 | 0.85 | SYK (0.62) | SYKNTRK1FCER2NTRK3NTRK2 | |
| SCHEMBL7138552 | 0.83 | ADAMTS5 (0.56) | ADAMTS5NTRK1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |