Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | FCER2 | P06734 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 6/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | FYN | P06241 | 3/20 | 0.43 |
| ▸ | YES1 | P07947 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368747 | 0.93 | SRC (0.51) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL7131357 | 0.92 | SYK (0.57) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL7130884 | 0.90 | ADAMTS5 (0.51) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL7137038 | 0.89 | SYK (0.49) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL7132123 | 0.87 | SYK (0.62) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL7136635 | 0.87 | NTRK1 (0.55) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL7132857 | 0.86 | SYK (0.47) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL7136938 | 0.84 | MOGAT2 (0.50) | CDK2ADAMTS5MEN1NPC1POLB | |
| SCHEMBL7136883 | 0.84 | SRC (0.58) | NTRK1SYKFCER2NTRK3NTRK2 | |
| SCHEMBL7133195 | 0.82 | MAOA (0.50) | NTRK1SYKFCER2NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |