Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOGAT2 | Q3SYC2 | 4/20 | 0.50 |
| ▸ | MGAT2 | Q10469 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135580 | 0.94 | MOGAT2 (0.50) | MOGAT2MGAT2PGRARNR3C1 | |
| SCHEMBL7136938 | 0.94 | MOGAT2 (0.50) | MOGAT2MGAT2PGRARNR3C1 | |
| SCHEMBL5358123 | 0.93 | PGR (0.52) | MOGAT2MGAT2PGRARNR3C1 | |
| SCHEMBL7131347 | 0.92 | MOGAT2 (0.51) | MOGAT2MGAT2PGRARNR3C1 | |
| SCHEMBL7134876 | 0.90 | MOGAT2 (0.47) | MOGAT2MGAT2PGRARNR3C1 | |
| SCHEMBL7133915 | 0.88 | PGR (0.54) | MOGAT2MGAT2PGRARNR3C1 | |
| SCHEMBL7130884 | 0.87 | ADAMTS5 (0.51) | ADAMTS5SYK | |
| SCHEMBL5361465 | 0.87 | MOGAT2 (0.59) | MOGAT2MGAT2MEN1ALOX15MAPK1 | |
| SCHEMBL7136795 | 0.84 | AR (0.57) | MOGAT2MGAT2PGRARNR3C1 | |
| SCHEMBL5357745 | 0.83 | MOGAT2 (0.58) | MOGAT2MGAT2ARPRKDCPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |