SCHEMBL7132115

SCHEMBL7132115

COc1cc2cc(OC)c3c(c2cc1OC)C=CC(c1ccccc1)(c1ccccc1)O3

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 1/20 0.40
ACHE P22303 1/20 0.34
SOS1 Q07889 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CA13 Q8N1Q1 1/20 0.33
RAC1 P63000 2/20 0.33
WHR1 P49842 1/20 0.32
HPGD P15428 2/20 0.32
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NQO1 P15559 1/20 0.32
BCHE P06276 1/20 0.32
DPP4 P27487 1/20 0.32
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7128153 0.90 PDE4D (0.40) PDE4DACHESOS1CA12CA1
SCHEMBL7132099 0.88 KDM4E (0.39) PDE4DCA12CA1CA7CA9
SCHEMBL23800906 0.82 KDM4E (0.45) CA12CA1CA7CA9HPGD
SCHEMBL29565451 0.82 KDM4E (0.45) CA12CA1CA7CA9HPGD
SCHEMBL6131938 0.81 DHODH (0.40) HPGDALDH1A1KDM4EHSD17B10MEN1
SCHEMBL7784203 0.78 MEN1 (0.40) CA12CA1CA7CA9CA13
SCHEMBL6131929 0.77 KMT2A (0.39) HPGDALDH1A1KDM4ECYP3A4CYP2C19
SCHEMBL8782497 0.77 TSHR (0.36) HPGDSMN1; SMN2ALDH1A1KDM4EMEN1
SCHEMBL5101461 0.76 MEN1 (0.33) CA1SMN1; SMN2ALDH1A1KDM4EMEN1
SCHEMBL5097868 0.75 NR3C1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0628064-B2 PHOTOCHROMIC NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2003-12-10 EP disclosed
EP-0628064-B1 PHOTOCHROMIC NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 1999-04-07 EP disclosed
EP-0628064-A1 PHOTOCHROMIC NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 1994-12-14 EP disclosed
US-5369158-A And polymer TRANSITIONS OPTICAL, INC. (US) 1994-11-29 US disclosed
WO-1993017071-A1 PHOTOCHROMIC NAPHTHOPYRANS PPG INDUSTRIES, INC. (US) 1993-09-02 WO disclosed
US-5238981-A PHOTOCHROMIC NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 1993-08-24 US disclosed