Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | FGB | P02675 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5101461 | 0.81 | MEN1 (0.33) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL5097868 | 0.81 | NR3C1 (0.32) | — | |
| SCHEMBL7784212 | 0.81 | PDK2 (0.31) | BCHEIDO1SIRT1 | |
| SCHEMBL7793584 | 0.80 | NR3C1 (0.33) | MEN1KMT2AALDH1A1KDM4EGPR84 | |
| SCHEMBL7789943 | 0.79 | PDK2 (0.34) | BCHEGPR84SIRT1 | |
| SCHEMBL7132115 | 0.78 | PDE4D (0.40) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4010989 | 0.77 | HSD17B10 (0.34) | MEN1KMT2AMAPTALDH1A1USP2 | |
| SCHEMBL14444797 | 0.77 | DRD2 (0.34) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13766143 | 0.77 | DRD2 (0.34) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL5108070 | 0.76 | HCAR2 (0.31) | GPR84SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042312-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHO[2,1-b]PYRANS | TRANSITIONS OPTICAL INC (US) | 2001-11-07 | — | — | EP | claimed |
| EP-1042312-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHO[2,1-b]PYRANS | TRANSITIONS OPTICAL INC (US) | 2001-11-07 | — | — | EP | disclosed |
| US-5869658-A | POLYMERIC ORGANIC HOST MATERIALS THAT CONTAIN OR THAT ARE COATED WITH THE NOVEL NAPHTHOPYRAN COMPOUNDS, LENSES | PPG INDUSTRIES, INC. (US) | 1999-02-09 | — | — | US | disclosed |