Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7792739 | 0.88 | CA1 (0.35) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL14444797 | 0.86 | DRD2 (0.34) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7784216 | 0.85 | MEN1 (0.31) | MEN1KMT2ACA1CA2CA4 | |
| SCHEMBL6890929 | 0.84 | STK10 (0.35) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL6889466 | 0.83 | LPAR5 (0.30) | — | |
| SCHEMBL6888923 | 0.83 | STK10 (0.33) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL6888729 | 0.82 | BCHE (0.32) | MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7784203 | 0.81 | MEN1 (0.40) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL21877308 | 0.81 | CA1 (0.35) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL13880301 | 0.80 | KDR (0.38) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320826-B2 | comprises 3-(4-methoxyphenyl)-3-phenyl-6,7,10,11-tetramethoxy-13-ethyl-13-hydroxy-13H-3H-indeno[2,'3,'3,4]naphtho[1,2-b]pyran; for activation via actinic radiation; improved optical density response; ophthalmic lens | PPG INDUSTRIES OHIO, INC. (US) | 2008-01-22 | — | — | US | claimed |
| US-20040191520-A1 | Photochromic articles with reduced temperature dependency and methods for preparation | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-30 | — | — | US | claimed |
| EP-1042312-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHO[2,1-b]PYRANS | TRANSITIONS OPTICAL INC (US) | 2001-11-07 | — | — | EP | claimed |
| US-7320826-B2 | comprises 3-(4-methoxyphenyl)-3-phenyl-6,7,10,11-tetramethoxy-13-ethyl-13-hydroxy-13H-3H-indeno[2,'3,'3,4]naphtho[1,2-b]pyran; for activation via actinic radiation; improved optical density response; ophthalmic lens | PPG INDUSTRIES OHIO, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040191520-A1 | Photochromic articles with reduced temperature dependency and methods for preparation | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-30 | — | — | US | disclosed |
| EP-1042312-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHO[2,1-b]PYRANS | TRANSITIONS OPTICAL INC (US) | 2001-11-07 | — | — | EP | disclosed |